Metabolomic profiling of M. speciosa champ at different growth stages

文献类型： 外文期刊

第一作者： Wang, Maoyuan

作者： Wang, Maoyuan;Yang, Qing;Wang, Qinglong;Li, Zhiying;Tang, Huan;Wang, Zhunian;Wang, Maoyuan;Yang, Qing;Wang, Qinglong;Li, Zhiying;Tang, Huan;Wang, Zhunian;Wang, Maoyuan;Yang, Qing;Wang, Qinglong;Li, Zhiying;Tang, Huan;Wang, Zhunian;Zhang, Mei;Ma, Bokai;Cheng, Wen;Feng, Shixiu

作者机构：

关键词： Millettia speciosa Champ; NMR; UPLC-Q-TOF-MS metabolomics; Nonalcoholic fatty liver disease; Growth stages

期刊名称：FOOD CHEMISTRY （ 影响因子：9.231； 五年影响因子：8.795 ）

ISSN： 0308-8146

年卷期： 2022 年 376 卷

页码：

收录情况： SCI

摘要： Millettia speciosa Champ (M. speciosa) is an edible food and folk medicine and extracts from its roots exhibit a hepatoprotective effect. However, its metabolic growth process and the best harvest time have not been reported. This study systematically evaluated the metabolomic profiling of M. speciosa root extracts at different growth stages through the UPLC-Q-TOF-MS, nuclear magnetic resonance (NMR) and An orthogonal partial least squares-discriminant analysis (OPLS-DA). The results revealed there were significant differences among extracts from six ages of M. speciosa, and 110 compounds were identified. Pharmacological studies showed that 5-year and 20-year old M. speciosa roots may exhibit higher fat-lowering effects, while 5-year-old (M.s-5Y) showed better hepatoprotective activity in high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) mice. Hence, our study suggested that M.s-5Y may have potent efficacy in ameliorating NAFLD, which might be useful in determining the optimum time to harvest M. speciosa.

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