Preparation of polysaccharide-based nanoparticles by chitosan and flaxseed gum polyelectrolyte complexation as carriers for bighead carp (Aristichthys nobilis) peptide delivery

文献类型： 外文期刊

第一作者： Zheng, Changliang

作者： Zheng, Changliang;Chen, Mengting;Shi, Liu;Qiao, Yu;Li, Xin;Guo, Xiaojia;Wang, Lan;Wu, Wenjin;Zheng, Changliang;Qu, Yinghong;Shi, Wenzheng;Chen, Yashu

作者机构：

关键词： Chitosan; Flaxseed gum; Polyelectrolyte complexation; Bighead carp peptide; Control release

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2023 年 249 卷

页码：

收录情况： SCI

摘要： Polysaccharide-based nanoparticles formed by the polyelectrolyte complexation between chitosan (CS) and flaxseed gum (FG) was developed in this work, and it was further used as a carrier for bighead carp peptide (BCP) delivery. The CS molecular weight (MW) of 50 kDa and CS/FG mass ratio of 1:2 at pH 3.5 were optimal conditions for the NP preparation, with the minimum particle size (similar to 155.1 nm) and the maximum BCP encapsulation efficiency (60.3 %). The BCP-loaded CS/FG NPs exhibited the smallest particle size (175.8 nm). Both CS/FG NPs and CS/FG-BCP NPs exhibited roughly uniform spherical shape. FT-IR spectra confirmed the existence of hydrogen bonds and electrostatic interactions in the nanoparticles. The BCP-loaded NPs displayed a higher thermal stability than BCP. Moreover, the release of BCP was controllable and dose-dependent, following a firstorder kinetics model. These findings suggested that our CS/FG NPs are a promising carrier for bioactive peptide delivery.

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