文献类型： 外文期刊
第一作者： Davaatseren, Munkhtugs
作者： Davaatseren, Munkhtugs;Hwang, Jin-Taek;Park, Jae Ho;Kim, Myung-Sunny;Sung, Mi Jeong;Davaatseren, Munkhtugs;Wang, Shuaiyu
作者机构：
期刊名称：MEDIATORS OF INFLAMMATION （ 影响因子：4.711； 五年影响因子：5.34 ）
ISSN： 0962-9351
年卷期： 2013 年
页码：
收录情况： SCI
摘要： Poly-gamma-glutamic acid (gamma-PGA), naturally secreted from various strains of Bacillus, has anti-inflammatory activity. In inflammatory bowel disease (IBD), inflammation is promoted and sustained by angiogenesis; however, the role played by gamma-PGA in this condition is unclear. Therefore, we evaluated gamma-PGA effects on angiogenesis and inflammation in a dextran sulfate sodium-(DSS-) induced mouse colitis model. Experimental colitis was induced in male C57BL/6 mice by administering 3% DSS. Disease activity index (DAI), histopathological scores, microvascular density, myeloperoxidase activity, and VEGF-A and VEGFR2 expression were compared among control mice, DSS-treated mice, and mice receiving 3% DSS along with gamma-PGA at 50 mg/kg body weight per day or 3% DSS with gamma-PGA at 200 mg/kg bodyweight per day. We found that gamma-PGA significantly attenuated weight loss, DAI, and colon shortening. gamma-PGA also significantly reduced histopathological evidence of injury. Moreover, gamma-PGA significantly attenuated DSS-induced blood vessel densities. Furthermore, gamma-PGA attenuated DSS-induced expression of VEGF-A and its receptor, VEGFR2. In addition, gamma-PGA treatment led to reduced recruitment of leukocytes to the inflamed colon. Therefore, our results indicate that gamma-PGA has potential application in conditions marked by inflammatory-driven angiogenesis and mucosal inflammation.
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