Identification of Triazolo-quinazolinone Derivatives as Novel and Potent Chitinase OfChi-h Inhibitors Based on Structure-Based Virtual Screening

文献类型： 外文期刊

第一作者： Dong, Lili

作者： Dong, Lili;Ding, Baokang;Yang, Meiling;Liu, Yaxin;Chen, Ziyang;Cao, Qingnan;Gao, Yongming;Ma, Shujie;Zhang, Lihui;Dong, Jingao;Jiang, Xi;Chen, Wei;Yang, Qing;Shen, Shengqiang;Jiang, Xi;Yang, Qing

作者机构：

关键词： triazolo-quinazolinone; chitinase; OfChi-h; Ostrinia furnacalis; virtual screening

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）

ISSN： 0021-8561

年卷期： 2023 年 71 卷 45 期

页码：

收录情况： SCI

摘要： Insect chitinase, OfChi-h, from Ostrinia furnacalis, is considered as a promising target for the development of green pesticides. On the basis of the crystal structure of OfChi-h, we successfully obtained a triazolo-quinazolinone scaffold as the novel class of OfChi-h inhibitor via a structure-based virtual screening approach. Rational compound screening enabled us to acquire a potent OfChi-h inhibitor TQ19 with a K( i )value of 0.33 mu M. Furthermore, the in vivo biological activity of target compounds was assayed. The results showed that compounds TQ8 and TQ19 could dramatically inhibit the growth and development of Ostrinia nubilalis larvae, and most of the compounds showed higher insecticidal activity than hexaflumuron. This present work reveals that triazolo-quinazolinone derivatives can serve as novel candidates for insect growth regulators.

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