Molecular Characterization and Gene Expression Analysis of Aquaporin in Haemaphysalis qinghaiensis

文献类型： 外文期刊

第一作者： Niu, Qingli

作者： Niu, Qingli;Hao, Rongzeng;Pan, Yuping;Liu, Zhijie;Yang, Jifei;Guan, Guiquan;Luo, Jianxun;Yin, Hong;Yin, Hong

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关键词： ticks; Haemaphysalis qinghaiensis; aquaporin; transcript variants; gene expression

期刊名称：FRONTIERS IN PHYSIOLOGY （ 影响因子：4.755； 五年影响因子：5.316 ）

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年卷期： 2022 年 13 卷

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收录情况： SCI

摘要： Aquaporins (AQPs) are important functional proteins and are widely present in the cell membrane of almost all organisms, mediating transmembrane transport of liquid and other solutes. Much is known about the molecular characterization of AQPs in other tick species; however, nothing is known about them in Haemaphysalis qinghaiensis. In this study, we first sequenced the transcript variants of AQPs in H. qinghaiensis (HqAQPs), analyzed the biological structure features of AQPs, and investigated the pattern of gene expression of the AQP gene of H. qinghaiensis in different tick tissues and stages to predict their biological functions. In conclusion, four AQP transcript variants (i.e., HqAQP1-1, HqAQP1-2, HqAQP1-3, and HqAQP1-4) of H. qinghaiensis were found, and the sequences were comparable with its orthologs from the reported tick species. Gene expression of AQPs in different tick tissues and stages showed the higher expression level in salivary glands and gut of adult female, as well as in the female and nymph than in Malpighian tubules, ovary, male, larvae, and egg. Further studies will be performed to evaluate the function of HqAQPs against H. qinghaiensis infestation on animals.

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