Male-specific bacteriophages and their potential on combating the spreading of T4SS-bearing antimicrobial resistance plasmids

文献类型： 外文期刊

第一作者： Li, Jun

作者： Li, Jun;Ji, Xing;Wang, Ran;He, Tao;Garcia, Pilar

作者机构：

关键词： Antimicrobial resistance; type IV secretion systems; T4SS; conjugation; male-specific phages

期刊名称：CRITICAL REVIEWS IN MICROBIOLOGY （ 影响因子：5.1； 五年影响因子：7.5 ）

ISSN： 1040-841X

年卷期： 2025 年 51 卷 4 期

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收录情况： SCI

摘要： Antimicrobial resistance (AMR) has been recognized as an important health crisis in the twenty first century. Type IV secretion systems (T4SSs) play key roles in the dissemination of AMR plasmids. Novel strategies that combat AMR problem by targeting T4SS sprung up in recent years. Here, we focus on the strategy of male-specific phages that could target and kill bacteria carrying conjugative AMR plasmids encoding T4SSs. We reviewed the recent advances in male-specific phages, including anti-conjugation mechanisms, clinical isolation and identification methods, classification and characteristics, in vitro and in vivo anti-conjugation efficacy and improving strategies. Male-specific phages constitute exciting candidates for developing sustainable anti-resistance biocontrol applications.

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