Detoxification of the Mycotoxin Citrinin by a Manganese Peroxidase from Moniliophthora roreri

文献类型： 外文期刊

第一作者： Wang, Shuai

作者： Wang, Shuai;Zhang, Yuhong;Liu, Bo;Zhang, Wei;Wang, Xiaolu;Huang, Huoqing;Tu, Tao;Luo, Huiying;Yao, Bin;Su, Xiaoyun

作者机构：

关键词： citrinin; manganese peroxidase; mycotoxin; red yeast rice; detoxification

期刊名称：TOXINS （ 影响因子：4.2； 五年影响因子：4.7 ）

ISSN：

年卷期： 2022 年 14 卷 11 期

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收录情况： SCI

摘要： Citrinin (CIT) is a mycotoxin found in foods and feeds and most commonly discovered in red yeast rice, a food additive made from ordinary rice by fermentation with Monascus. Currently, no enzyme is known to be able to degrade CIT effectively. In this study, it was discovered that manganese peroxidase (MrMnP) from Moniliophthora roreri could degrade CIT. The degradation appeared to be fulfilled by a combination of direct and indirect actions of the MrMnP with the CIT. Pure CIT, at a final concentration of 10 mg/L, was completely degraded by MrMnP within 72 h. One degradation product was identified to be dihydrocitrinone. The toxicity of the CIT-degradation product decreased, as monitored by the increased survival rate of the Caco-2 cells incubated with MrMnP-treated CIT. In addition, MrMnP could degrade CIT (with a starting concentration of up to 4.6 mg/L) completely contaminated in red yeast rice. MrMnP serves as an excellent candidate enzyme for CIT detoxification.

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