Hawthorn (Crataegus pinnatifida Bunge) polysaccharide improves the adaptability of crucian carp (Carassius auratus) to high alkalinity by regulating immunity, intestinal microbiota, and intestinal metabolomics

文献类型： 外文期刊

第一作者： Luo, Liang

作者： Luo, Liang;Meng, Xianwei;Wang, Shihui;Zhang, Rui;Guo, Kun;Zhao, Zhigang;Luo, Liang;Wang, Wei

作者机构：

关键词： Hawthorn polysaccharide; Carbonate alkalinity; Immune; Intestinal microbiota; Intestinal metabolomics

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 320 卷

页码：

收录情况： SCI

摘要： Hawthorn (Crataegus pinnatifida Bunge) polysaccharide (HP) is one of the most important active ingredients in hawthorn and has antioxidant and immunomodulatory effects. However, HP is rarely used in aquaculture research. High alkalinity adversely affects the growth and development of aquatic organisms; therefore, new feed additives that eliminate the adverse effects high alkalinity are warranted. Therefore, in this study, we investigated the effects of HP on crucian carp under carbonate stress. HP decreased of malondialdehyde content by increasing total antioxidant capacity through up-regulation of superoxide dismutase, catalase, and glutathione peroxidase. Increased serum lysozyme and acid phosphatase activities, decreased serum alkaline phosphatase activity, and altered tumor necrosis factor-alpha (tnf-alpha), interleukin (il-10, il-8), and transforming growth factor-beta (tgf-(1) mRNA expression. This improved the antioxidant properties and immune capacity of crucian carp. Additionally, HP altered the species richness and structure of the crucian carp intestinal flora, reduced the abundance of harmful Proteobacteria, Actinobacteria, and Bacteroidetes, and increased the abundance of beneficial Firmicutes. Using liquid chromatography-mass spectrometry analysis, 168 different metabolites were detected, and alanine, aspartate, and glutamate metabolism were the most important metabolic pathways. Therefore, adding HP to feed alleviated body damage caused by alkalinity stress in crucian carp. Thus, this study provides new insights into the effects of HP on organisms in aquaculture.

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