A Review of the Biological Activities of Heterocyclic Compounds Comprising Oxadiazole Moieties
文献类型： 外文期刊
第一作者： Ruan, Ban-Feng
作者： Ruan, Ban-Feng;Li, Lu-Zhi;Ruan, Ban-Feng;Guo, Qing-Lei;Li, Qing-Shan;Deora, Girdhar Singh;Zhou, Ben-Guo
作者机构：
关键词： Heterocyclic compounds; Oxadiazole; Anticancer; Antibacterial; Anti-inflammatory; SAR
期刊名称：CURRENT TOPICS IN MEDICINAL CHEMISTRY （ 影响因子：3.57； 五年影响因子：4.255 ）
ISSN： 1568-0266
年卷期： 2022 年 22 卷 7 期
页码：
收录情况： SCI
摘要： The oxadiazole core is considered a privileged moiety in many medicinal chemistry applications. The oxadiazole class includes 1,2,3-oxadiazole, 1,2,4-oxadiazole, 1,3,4-oxadiazole, and 1,2,5-oxadiazole. Compounds bearing an oxadiazole ring show a wide range of biological activities, such as anticancer, antibacterial, anti-inflammatory, anti-malarial, and insecticidal properties. Among oxadiazoles, the 1,3,4-oxadiazole has been the most widely explored moiety in medicinal chemistry research. This review is primarily focused on the anticancer, antibacterial, and anti-inflammatory activities of compounds containing 1,2,4-oxadiazole, 1,3,4-oxadiazole and 1,2,5-oxadiazole reported in the last five years.
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