Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis

文献类型： 外文期刊

第一作者： Ou, Zhihua

作者： Ou, Zhihua;Ren, Peidi;He, Fan;Chen, Jialing;Tan, Qiming;Chen, Qi;Zhang, Qian;Ou, Zhihua;Ren, Peidi;He, Fan;Chen, Jialing;Cai, Huimin;Li, Jiandong;Tan, Qiming;Chen, Qi;He, Xiuju;Zhao, Yanping;Zhang, Qian;Liang, Yingan;Li, Junhua;Li, Li;Zhou, Ting-Ting;Wu, Yao-Dong;Li, Xiu-Rong;Li, Wenhui;Zhang, Nian-Zhang;Chen, Wei-Gang;Sun, Jiwen;Wu, Yan-Tao;You, Jie;Tian, Xue-Qi;Fu, Bao-Quan;Cai, Xue-Peng;Jia, Wan-Zhong;Yan, Hong-Bin;Li, Li;Zhou, Ting-Ting;Wu, Yao-Dong;Li, Xiu-Rong;Li, Wenhui;Zhang, Nian-Zhang;Chen, Wei-Gang;Sun, Jiwen;Wu, Yan-Tao;You, Jie;Tian, Xue-Qi;Fu, Bao-Quan;Cai, Xue-Peng;Jia, Wan-Zhong;Yan, Hong-Bin;He, Fan;Chen, Jialing;Chen, Qi;Zhang, Qian;Cai, Huimin;Li, Jiandong;He, Xiuju;Zhao, Yanping;Liao, Sha;Yang, Huanming;Wang, Jian;Jin, Xin;Xu, Xun;Han, Xiumin;Tan, Qiming;Liang, Yingan;Hu, Guohai;Wang, Jian;Chen, Ao;Chen, Ao;Jin, Xin;Jin, Xin;Xu, Xun;Li, Junhua

作者机构：

关键词： Echinococcus multilocularis; macrophages; neutrophils; single-cell RNA sequencing; spatial transcriptomics

期刊名称：ADVANCED SCIENCE （ 影响因子：14.1； 五年影响因子：15.6 ）

ISSN：

年卷期： 2025 年 12 卷 18 期

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收录情况： SCI

摘要： Alveolar echinococcosis (AE) is caused by the chronic infection of E. multilocularis, whose tumor-like growth can lead to high fatality if improperly treated. The early diagnosis of infection and the treatment of advanced AE remain challenging. Herein, bulk RNA-seq, scRNA-seq, and spatial transcriptomics technologies are integrated, to reveal the host immune response mechanism against E. multilocularis both spatially and chronologically, collecting mouse liver samples at multiple timepoints up to 15 months post infection. These results unveil an unprecedented high-resolution spatial atlas of the E. multilocularis infection foci and the functional roles of neutrophils, Spp1+ macrophages, and fibroblasts during disease progression. The heterogeneity of neutrophil and macrophage subpopulations are critical in both parasite-killing and the occurrence of immunosuppression during AE progression. These findings indicate the transition of parasite control strategy from "active killing" to "negative segregation" by the host, providing instructive insights into the treatment strategy for echinococcosis.

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