ICVAE: Interpretable Conditional Variational Autoencoder for De Novo Molecular Design

文献类型： 外文期刊

第一作者： Fan, Xiaqiong

作者： Fan, Xiaqiong;Yue, Minghan;Li, Jiamin;Ren, Xiaozhen;Fang, Senlin;Li, Zhengyan;Ji, Hongchao;Li, Zhengyan

作者机构：

关键词： molecular generation; variational autoencoder; drug discovery

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：4.9； 五年影响因子：5.7 ）

ISSN： 1661-6596

年卷期： 2025 年 26 卷 9 期

页码：

收录情况： SCI

摘要： Recent studies have demonstrated that machine learning-based generative models can create novel molecules with desirable properties. Among them, Conditional Variational Autoencoder (CVAE) is a powerful approach to generate molecules with desired physiochemical and pharmacological properties. However, the CVAE's latent space is still a black-box, making it difficult to understand the relationship between the latent space and molecular properties. To address this issue, we propose the Interpretable Conditional Variational Autoencoder (ICVAE), which introduces a modified loss function that correlates the latent value with molecular properties. ICVAE established a linear mapping between latent variables and molecular properties. This linearity is not only crucial for improving interpretability, by assigning clear semantic meaning to latent dimensions, but also provides a practical advantage. It enables direct manipulation of molecular attributes through simple coordinate shifts in latent space, rather than relying on opaque, black-box optimization algorithms. Our experimental results show that the ICVAE can linearly relate one or multiple molecular properties with the latent value and generate molecules with precise properties by controlling the latent values. The ICVAE's interpretability allows us to gain insight into the molecular generation process, making it a promising approach in drug discovery and material design.

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