Recent Advances in Assembly of Complex Plant Genomes

文献类型： 外文期刊

第一作者： Kong, Weilong

作者： Kong, Weilong;Wang, Yibin;Zhang, Shengcheng;Yu, Jiaxin;Zhang, Xingtan

作者机构：

关键词： Complex plant genome; Assembly algorithm; Telomere-to-telomere genome; Haplotype-resolved assembly; Sequencing technology

期刊名称：GENOMICS PROTEOMICS & BIOINFORMATICS （ 影响因子：9.5； 五年影响因子：10.1 ）

ISSN： 1672-0229

年卷期： 2023 年 21 卷 3 期

页码：

收录情况： SCI

摘要： Over the past 20 years, tremendous advances in sequencing technologies and computational algorithms have spurred plant genomic research into a thriving era with hundreds of genomes decoded already, ranging from those of nonvascular plants to those of flowering plants. However, complex plant genome assembly is still challenging and remains difficult to fully resolve with conventional sequencing and assembly methods due to high heterozygosity, highly repetitive sequences, or high ploidy characteristics of complex genomes. Herein, we summarize the challenges of and advances in complex plant genome assembly, including feasible experimental strategies, upgrades to sequencing technology, existing assembly methods, and different phasing algorithms. Moreover, we list actual cases of complex genome projects for readers to refer to and draw upon to solve future problems related to complex genomes. Finally, we expect that the accurate, gapless, telomere-to-telomere, and fully phased assembly of complex plant genomes could soon become routine.

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