Androgen rather than estrogen up-regulates brain-type cytochrome P450 aromatase (cyp19a1b) gene via tissue-specific promoters in the hermaphrodite teleost ricefield eel Monopterus albus

文献类型： 外文期刊

第一作者： Zhang, Yang

作者： Zhang, Yang;Zhang, Shen;Zhou, Wenliang;Lin, Haoran;Zhang, Weimin;Zhang, Lihong;Lin, Haoran;Zhang, Weimin;Ye, Xing;Ge, Wei;Cheng, Christopher H. K.

作者机构：

关键词： Monopterus albus;cyp19a1b;Tissue-specific promoter;Estrogen;Androgen

期刊名称：MOLECULAR AND CELLULAR ENDOCRINOLOGY （ 影响因子：4.102； 五年影响因子：4.226 ）

ISSN： 0303-7207

年卷期： 2012 年 350 卷 1 期

页码：

收录情况： SCI

摘要： CYP19A1 in the brain and pituitary of vertebrates is important for reproductive and non-reproductive processes. In teleosts, it is broadly accepted that estradiol (E-2) up-regulates cyp19a1b gene via a positive autoregulatory loop. Our present study, however, showed that E-2 did not up-regulate ricefield eel cyp19a1b in the hypothalamus and pituitary, whereas dihydrotestosterone (DHT) or testosterone (T) stimulated cyp19a1b expression only in the pituitary. Two tissue-specific promoters, namely promoter I and II directing the expression in the brain and pituitary respectively, were identified. Promoter I contained a non-consensus estrogen response element (ERE), and consequently did not respond to E-2. Promoter II contained an androgen response element (ARE) and consequently responded to DHT. Taken together, these results demonstrated a novel steroidal regulation of cyp19a1b gene expression and an alternative usage of tissue-specific cyp19a1b promoters in the brain and pituitary of a teleost species, the ricefield eel. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

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