Grey Relationship optimization based structural design Inspired by Cantor fractals for micromixers in nanoliposome preparation

文献类型： 外文期刊

第一作者： Zhou, Wei

作者： Zhou, Wei;Zhang, Wenqiang;Liang, Chao;Deng, Xue;Xu, Wentao

作者机构：

关键词： Microfluidic chips; Cantor fractal theory; Fluid control; Mixing; Nanoliposome Preparation

期刊名称：CHEMICAL ENGINEERING SCIENCE （ 影响因子：4.3； 五年影响因子：4.3 ）

ISSN： 0009-2509

年卷期： 2025 年 308 卷

页码：

收录情况： SCI

摘要： Efficient fluid blending in small-volume flow channels with high throughput is essential for the preparation of nanoliposomes. However, designing micromixer channel structures that optimize mixing efficiency while minimizing pressure drop remains a significant challenge. To address this, we developed a micromixer based on Cantor fractal theory, incorporating cantilevered baffles on both the side and bottom surfaces. The configuration was optimized using grey relational analysis. This micromixer achieved a mixing efficiency of 0.9960 and a Poiseuille number of 647.92, demonstrating superior mixing performance and operational safety. Laser engraving was utilized to fabricate the complex flow channel structure, producing nanoliposomes with a mean particle size of 128 nm and a polydispersity index of 0.23. Furthermore, our findings reveal that the channel's depth-to-width ratio significantly impacts both mixing efficiency and power consumption, underscoring its reliability and scalability for high-flow-rate applications.

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