Identification of the RNA-binding domain-containing protein RbpA that acts as a global regulator of the pathogenicity of Streptococcus suis serotype 2

文献类型： 外文期刊

第一作者： Zhong, Xiaojun

作者： Zhong, Xiaojun;Ma, Jiale;Bai, Qiankun;Zhu, Yinchu;Zhang, Yue;Gu, Qibing;Pan, Zihao;Liu, Guangjin;Wu, Zongfu;Yao, Huochun;Zhu, Yinchu;Zhang, Yue

作者机构：

关键词： Streptococcus suis; RNA-binding protein; Rbpa; pathogenicity; post-transcriptional regulation

期刊名称：VIRULENCE （ 影响因子：5.428； 五年影响因子：6.735 ）

ISSN： 2150-5594

年卷期： 2022 年 13 卷 1 期

页码：

收录情况： SCI

摘要： Streptococcus suis serotype 2 (SS2), an emerging zoonotic pathogen, causes swine diseases and human cases of streptococcal toxic shock syndrome. RNA-binding proteins (RBPs) can modulate gene expression through post-transcriptional regulation. In this study, we identified an RBP harbouring an S1 domain, named RbpA, which facilitated SS2 adhesion to host epithelial cells and contributed to bacterial pathogenicity. Comparative proteomic analysis identified 145 proteins that were expressed differentially between Delta rbpA strain and wild-type strain, including several virulence-associated factors, such as the extracellular protein factor (EF), SrtF pilus, IgA1 protease, SBP2 pilus, and peptidoglycan-binding LysM' proteins. The mechanisms underlying the regulatory effects of RbpA on their encoding genes were explored, and it was found that RbpA regulates gene expression through diverse mechanisms, including post-transcriptional regulation, and thus acts as a global regulator. These results partly reveal the pathogenic mechanism mediated by RbpA, improving our understanding of the regulatory systems of S. suis and providing new insights into bacterial pathogenicity.

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