Exploring the Therapeutic Potential of Royal Jelly in Metabolic Disorders and Gastrointestinal Diseases

文献类型： 外文期刊

第一作者： El-Seedi, Hesham R.

作者： El-Seedi, Hesham R.;El-Seedi, Hesham R.;Guo, Zhiming;El-Seedi, Hesham R.;Salama, Suzy;El-Wahed, Aida A. Abd;Di Minno, Alessandro;Daglia, Maria;Buccato, Daniele Giuseppe;Di Minno, Alessandro;Daglia, Maria;Li, Chuan;Guan, Xiao;Guan, Xiao;Khalifa, Shaden A. M.;Wang, Kai

作者机构：

关键词： royal jelly; diabetes mellitus; gastrointestinal diseases; cardiovascular diseases; bioactive compounds

期刊名称：NUTRIENTS （ 影响因子：5.9； 五年影响因子：6.6 ）

ISSN：

年卷期： 2024 年 16 卷 3 期

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收录情况： SCI

摘要： Metabolic disorders, encompassing diabetes mellitus, cardiovascular diseases, gastrointestinal disorders, etc., pose a substantial global health threat, with rising morbidity and mortality rates. Addressing these disorders is crucial, as conventional drugs often come with high costs and adverse effects. This review explores the potential of royal jelly (RJ), a natural bee product rich in bioactive components, as an alternative strategy for managing metabolic diseases. RJ exhibits diverse therapeutic properties, including antimicrobial, estrogen-like, anti-inflammatory, hypotensive, anticancer, and antioxidant effects. This review's focus is on investigating how RJ and its components impact conditions like diabetes mellitus, cardiovascular disease, and gastrointestinal illnesses. Evidence suggests that RJ serves as a complementary treatment for various health issues, notably demonstrating cholesterol- and glucose-lowering effects in diabetic rats. Specific RJ-derived metabolites, such as 10-hydroxy-2-decenoic acid (10-HDA), also known as the "Queen bee acid," show promise in reducing insulin resistance and hyperglycemia. Recent research highlights RJ's role in modulating immune responses, enhancing anti-inflammatory cytokines, and suppressing key inflammatory mediators. Despite these promising findings, further research is needed to comprehensively understand the mechanisms underlying RJ's therapeutic effects.

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