Protective Effect of Artocarpus heterophyllus Lam. (Jackfruit) Polysaccharides on Liver Injury Induced by Cyclophosphamide in Mice

文献类型： 外文期刊

第一作者： Cheng, Ming

作者： Cheng, Ming;Zheng, Yifan;Wu, Gang;Tan, Lehe;Xu, Fei;Zhang, Yanjun;Chen, Xiaoai;Zhu, Kexue;Cheng, Ming;Zheng, Yifan;Wu, Gang;Xu, Fei;Zhang, Yanjun;Chen, Xiaoai;Zhu, Kexue;Xu, Fei;Zhang, Yanjun;Chen, Xiaoai;Zhu, Kexue

作者机构：

关键词： jackfruit polysaccharides; liver injury; protective effects; metabolomics

期刊名称：NUTRIENTS （ 影响因子：5.9； 五年影响因子：6.6 ）

ISSN：

年卷期： 2024 年 16 卷 1 期

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收录情况： SCI

摘要： In recent years, Artocarpus heterophyllus Lam. (jackfruit) polysaccharides (namely JFP-Ps) have attracted much attention due to their multiple biological activities. This study aimed to explore the protective effects and the underlying mechanisms of JFP-Ps on cyclophosphamide (Cp)-induced liver damage. The protective effect of JFP-Ps was evaluated using HE staining, antioxidant testing, enzyme-linked immunosorbent assay (ELISA), real-time quantitative polymerase chain reaction (RT-qPCR), Western blot and ultra-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) metabolomics analysis. The results showed that Cp caused pathological liver damage, activated oxidative stress and downregulated cytokine expression, while JFP-Ps treatment was found to exert antioxidant effects and play immune regulatory roles through mitogen-activated protein kinase/nuclear factor-kappa B (MAPK/NF-kappa B) related inflammation and cell apoptosis pathways to protect the Cp-induced liver injury. Metabolomic results showed that the liver-protective effects of JFP-Ps were mainly related to aminoacyl transfer ribonucleic acid (tRNA) biosynthesis, sphingolipid metabolism, purine metabolism and the citrate cycle. These results indicate that JFP-Ps have great potential application in alleviating liver injury.

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