Loss of NSE-4 Perturbs Genome Stability and DNA Repair in Caenorhabditis elegans

文献类型： 外文期刊

第一作者： Odiba, Arome Solomon

作者： Odiba, Arome Solomon;Ezechukwu, Chiemekam Samuel;Liao, Guiyan;Li, Siqiao;Fang, Wenxia;Jin, Cheng;Wang, Bin;Odiba, Arome Solomon;Jin, Cheng;Odiba, Arome Solomon;Ezechukwu, Chiemekam Samuel;Chen, Zhongliang;Liu, Xihui;Wang, Bin

作者机构：

关键词： C; elegans; DNA repair; meiosis; mitosis; NSE-4; SMC-5; 6 complex

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：6.208； 五年影响因子：6.628 ）

ISSN：

年卷期： 2022 年 23 卷 13 期

页码：

收录情况： SCI

摘要： The Structural Maintenance of Chromosomes (SMC) complex plays an important role in maintaining chromosome integrity, in which the SMC5/6 complex occupies a central position by facilitating mitotic and meiotic processes as well as DNA repair. NSE-4 Kleisin is critical for both the organization and function of the SMC5/6 complex, bridging NSE1 and NSE3 (MAGE related) with the head domains of the SMC5 and SMC6 proteins. Despite the conservation in protein sequence, no functional relevance of the NSE-4 homologous protein (NSE-4) in Caenorhabditis elegans has been reported. Here, we demonstrated the essential role of C. elegans NSE-4 in genome maintenance and DNA repair. Our results showed that NSE-4 is essential for the maintenance of chromosomal structure and repair of a range of chemically induced DNA damage. Furthermore, NSE-4 is involved in inter-sister repair during meiosis. NSE-4 localizes on the chromosome and is indispensable for the localization of NSE-1. Collectively, our data from this study provide further insight into the evolutionary conservation and diversification of NSE-4 function in the SMC-5/6 complex.

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[1]Loss of NSE-4 Perturbs Genome Stability and DNA Repair in Caenorhabditis elegans. Odiba, Arome Solomon,Ezechukwu, Chiemekam Samuel,Liao, Guiyan,Li, Siqiao,Fang, Wenxia,Jin, Cheng,Wang, Bin,Odiba, Arome Solomon,Jin, Cheng,Odiba, Arome Solomon,Ezechukwu, Chiemekam Samuel,Chen, Zhongliang,Liu, Xihui,Wang, Bin. 2022

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