A comprehensive study of the colloidal properties, biocompatibility, and synergistic antioxidant actions of Antarctic krill phospholipids

文献类型： 外文期刊

第一作者： Su, Dong

作者： Su, Dong;Zhang, Zipeng;Zhang, Yating;Zhao, Ling;Yu, Yueqin;Su, Dong;Wang, Xixi;Liu, Xiaofang;Miao, Junkui;Yu, Yuan;Leng, Kailiang;Leng, Kailiang;Leng, Kailiang

作者机构：

关键词： Antarctic krill; PUFAs-esterified phospholipid; Antioxidant; Synergy; Oxygen-sensitive

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2024 年 451 卷

页码：

收录情况： SCI

摘要： Excipient selection is crucial to address the oxidation and solubility challenges of bioactive substances, impacting their safety and efficacy. AKPL, a novel omega-3 polyunsaturated fatty acids (PUFAs) esterified phospholipid derived from Antarctic krill, demonstrates unique antioxidant capabilities and synergistic effects. It exhibits pronounced surface activity and electronegativity at physiological pH, as evidenced by a critical micelle concentration (CMC) of 0.15 g/L and zeta-potential of -49.9 mV. In aqueous environments, AKPL self -assembles into liposomal structures, offering high biocompatibility and promoting cell proliferation. Its polyunsaturated bond -rich structure provides additional oxidation sites, imparting antioxidant properties superior to other phospholipids like DSPC and DOPC. Additionally, AKPL augments the efficacy of lipophilic antioxidants, such as alpha-tocopherol and curcumin, in aqueous media through both intermolecular and intramolecular interactions. In sum, AKPL emerges as an innovative unsaturated phospholipid, offering new strategies for encapsulating and delivering oxygensensitive agents.

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