SARS-CoV-2-related pangolin coronavirus exhibits similar infection characteristics to SARS-CoV-2 and direct contact transmissibility in hamsters

文献类型： 外文期刊

第一作者： Guo, Zhendong

作者： Guo, Zhendong;Zhang, Cheng;Zhang, Chunmao;Jiang, Xinyun;Wang, Tiecheng;Li, Yuanguo;Liu, Jun;Wan, Zhonghai;Meng, Keyin;Li, Jiping;Gao, Yuwei;Zhang, Cheng;Cui, Huan;Tong, Yigang

作者机构：

期刊名称：ISCIENCE （ 影响因子：6.107； 五年影响因子：6.233 ）

ISSN：

年卷期： 2022 年 25 卷 6 期

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收录情况： SCI

摘要： To date, intermediate hosts of SARS-CoV-2 remain obscure and controversial. Several studies have shown that SARS-CoV-2-related pangolin coronavirus (Pangolin-CoV) has a high sequence similarity to SARS-CoV-2 and might be the initial source of SARS-CoV-2; however, the biological characteristics of Pangolin-CoV are still largely unknown. In this study, we evaluated the pathogenicity and transmissibility of Pangolin-CoV in Syrian golden hamsters Mesocricetus auratus (Linnaeus, 1758) and compared it with SARS-CoV-2. Pangolin-CoV could effectively infect hamsters, showed similar tissue tropism to SARS-CoV-2 and replicated efficiently in the respiratory system and brain. The infected hamsters had no weight loss but had obvious viral shedding and lung pathological injury. Notably, Pangolin-CoV could transmit between hamsters by direct contact but not via aerosols, and the infected hamsters could exhale infectious viral aerosols (>1 mu m). These results highlight the importance of continuous monitoring of coronaviruses in pangolins owing to the potential threat of PangolinCoV to human health.

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