Concentrated fish oil ameliorates non-alcoholic fatty liver disease by regulating fibroblast growth factor 21-adiponectin axis

文献类型： 外文期刊

第一作者： Guo, Xiao-Fei

作者： Guo, Xiao-Fei;Wang, Chong;Yang, Ting;Ma, Wen-Jun;Li, Duo;Guo, Xiao-Fei;Wang, Chong;Yang, Ting;Ma, Wen-Jun;Li, Duo;Zhai, Jie;Zhao, Ting;Xu, Tong-Cheng;Li, Jun;Liu, He;Sinclair, Andrew J.;Li, Duo;Li, Duo

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关键词： Fish oil; Non-alcoholic fatty liver disease; Fibroblast growth factor 21; Adiponectin

期刊名称：NUTRITION （ 影响因子：4.893； 五年影响因子：4.973 ）

ISSN： 0899-9007

年卷期： 2022 年 99-100 卷

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收录情况： SCI

摘要： Objectives: The fibroblast growth factor 21 (FGF21)-adiponectin axis participates in energy hemostasis and obesity-related syndrome. The present study aimed to investigate whether concentrated fish oil (FO) intervention could alleviate non-alcoholic fatty liver disease (NAFLD) via the regulation of the FGF21-adiponectin axis. Methods: In a randomized controlled trial, 61 patients with NAFLD, age 55.9 ?? 15.6 y, were randomly divided into two groups: FO (3 g/d; n = 30) and corn oil (CO; 3 g/d; n = 31), which served as the control group. Results: After a 3-mo intervention, there were significant net reductions in serum alanine transaminase (-5.4 ?? 14.5 U/L vs. -0.25 ?? 4.70 U/L; P = 0.001) and triacylglycerol (-0.70 ?? 1.10 mmol/L vs. 0.11 ?? 1.04 mmol/L; P = 0.018) levels in the FO group compared with the CO group. Furthermore, the mean changes of FGF21 levels (-16.3 ?? 20.1 pg/mL vs. 7.2 ?? 32.9 pg/mL; P = 0.002) were significantly decreased, but adiponectin levels (1.14 ?? 1.53 mg/mL vs. -0.42 ?? 2.04 pg/mL; P = 0.011) were significantly increased in the FO group compared with the CO group. In the animal study, the mice fed the high-fat diet demonstrated characteristics of NAFLD. The administration of FO significantly improved high-fat diet-induced hepatic steatosis, insulin resistance, and inflammation compared with the high-fat control group. In addition, FO improved the sensitivity of FGF21, and stimulated the expression levels of adiponectin in the liver. Conclusions: The present study suggested that FO could potentially ameliorate NAFLD through mediating the FGF21-adiponectin axis.

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