Dendrobium nobile Lindl ameliorates learning and memory deficits in scopolamine-treated mice

文献类型： 外文期刊

第一作者： Zhang, Qiumei

作者： Zhang, Qiumei;Li, Yujiao;Li, Zhi;Liu, Xinmin;Wang, Qiong;Zhang, Qiumei;Li, Yujiao;Fan, Bei;Wang, Fengzhong;Wang, Qiong;Liu, Xinmin;Dias, Alberto Carlos Pires;Dias, Alberto Carlos Pires

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关键词： Dendrobium nobile Lindl (DNL); Scopolamine; Mice; Learning and memory

期刊名称：JOURNAL OF ETHNOPHARMACOLOGY （ 影响因子：5.4； 五年影响因子：5.3 ）

ISSN： 0378-8741

年卷期： 2024 年 324 卷

页码：

收录情况： SCI

摘要： Ethnopharmacological relevance: Dendrobium nobile Lindl (DNL), a valued time-honored herb, possesses immuneboosting and age-delaying properties, has been widely used to treat hyperglycemia and neurological diseases, and is probably a potential drug for improving learning and memory. Scopolamine (Scop), an antagonist for muscarinic receptors, potentially impairing intelligence and memory. Aim of the study: This investigation aimed to assess the efficacy of DNL in alleviating scopolamine-induced cognitive deficits in mice and its mechanisms. Materials and methods: We utilized the open-field test, novel object recognition test (NOR), and Morris water maze test (MWM) to assess the potential of DNL in ameliorating learning and memory dysfunction caused by scopolamine in mice. Enzyme-linked immunosorbent assay (ELISA) was employed to measure Choline acetyltransferase (ChAT) content and Acetylcholinesterase (AChE) activities in the brain, and oxidative stress-related factors in the serum, including Malondialdehyde (MDA), Superoxide dismutase (SOD), and glutathione (GSH) content. Results: Scopolamine injection significantly reduced the discrimination index of mice in the NOR test and impaired their performance in the MWM test, as demonstrated by longer escape latency, fewer target crossings, and less time spent in the target quadrant in the MWM. After 25 days of administration, DNL increased the discrimination index of the scopolamine-treated mice in the NOR test. DNL reduced the escape latency in the MWM test in the model mice. DNL increased the target crossing number and the percentage of time spent in the target quadrant in the MWM test. ELISA experiments indicated that DNL decreased the AChE activities, increased the ChAT activities, and modulated oxidative stress makers (GSH, SOD, and MDA) in scopolamine-induced mice. Conclusions: DNL may improve the learning and memory in mice treated with scopolamine, possibly by modulating oxidative stress and impaired cholinergic function.

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