Toxic Effects of Aflatoxin B-1 in Chinese Sea Bass (Lateolabrax maculatus)

文献类型： 外文期刊

第一作者： Peng, Kai

作者： Peng, Kai;Chen, Bing;Zhao, Hongxia;Huang, Wen

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关键词： aflatoxin B-1; toxicity; Lateolabrax maculatus

期刊名称：TOXINS （ 影响因子：5.075； 五年影响因子：5.305 ）

ISSN：

年卷期： 2021 年 13 卷 12 期

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收录情况： SCI

摘要： This study was performed to assess the effects of dietary aflatoxin B-1 (AFB(1)) on the growth, antioxidant and immune response, digestive enzyme activities, and intestinal morphology of Lateolabrax maculatus during a 56-day feeding trial. Four diets were formulated including 0, 0.1, 0.5, and 1.0 mg/kg of AFB(1). Each diet was randomly assigned to 3 fish tanks with 40 fish per tank. Results indicated that the fish's final body weight, weight gain rate, specific growth rate, feed intake, condition factor, viscerosomatic index, hepatosomatic index, and intestinesomatic index decreased (p < 0.01) as dietary AFB(1) increased. AFB(1) levels in diets increased (p < 0.05) serum total antioxidant capacity (TAOC), superoxide (SOD), catalase, malondialdehyde (MDA), alkaline phosphatase (AKP), and lysozyme (LZM), and increased (p < 0.05) the TAOC, SOD, MDA, AKP, LZM, and immunoglobulin M in the livers of the fish. Dietary AFB(1) decreased (p < 0.05) intestinal trypsin activity and induced intestinal injury. In summary, dietary AFB(1) up to 1.0 mg/kg was toxic to L. maculatus as judged by reduced growth, enhanced antioxidant and immune response, decreased intestinal trypsin activity, and impaired intestinal morphology.

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