Limited accumulation of high-frequency somatic mutations in a 1700-year-old Osmanthus fragrans tree

文献类型： 外文期刊

第一作者： Duan, Yifan

作者： Duan, Yifan;Yan, Jiping;Zhu, Yue;Zhang, Cheng;Zhang, Min;Wang, Xianrong;Duan, Yifan;Yan, Jiping;Zhu, Yue;Zhang, Cheng;Zhang, Min;Wang, Xianrong;Tao, Xiuhua;Ji, Hongli;Wang, Long

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关键词： ageing; clonal variation; Osmanthus fragrans; somatic mutation; tree evolution

期刊名称：TREE PHYSIOLOGY （ 影响因子：4.561； 五年影响因子：5.121 ）

ISSN： 0829-318X

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收录情况： SCI

摘要： Lifespan varies greatly between and within species. Mutation accumulation is considered an important factor explaining this life-history trait. However, direct assessment of somatic mutations in long-lived species is still rare. In this study, we sequenced a 1700-year-old sweet olive tree and analysed the high-frequency somatic mutations accumulated in its six primary branches. We found the lowest per-year mutation accumulation rate in this oldest tree among those studied via the whole-genome sequencing approach. Investigation of mutation profiles suggests that this low rate of high-frequency mutation was unlikely to result from strong purifying selection. More intriguingly, on a per-branching scale, the high-frequency mutation accumulation rate was similar among the long-lived individuals such as oak, wild peach and sweet olive investigated here. We therefore suggest the possibility that the accumulation of high-frequency somatic mutations in very long-lived trees might have an upper boundary due to both the possible limited number of stem cell divisions and the early segregation of the stem cell lineage.

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