Equus roundworms (Parascaris univalens) are undergoing rapid divergence while genes involved in metabolic as well as anthelminic resistance are under positive selection

文献类型： 外文期刊

第一作者： Han, Lei

作者： Han, Lei;Lu, Yaxian;Zhou, Mengchao;Chai, Hongliang;Liu, Quan;Hou, Zhijun;Lan, Tianming;Liu, Huan;Lan, Tianming;Li, Haimeng;Wang, Qing;Sahu, Sunil Kumar;Wang, Sibo;Liu, Huan;Li, Haimeng;Wang, Qing;Lu, Haorong;Qian, Puyi;Zhang, Shaofang;Zhou, Hongcheng;Lu, Haorong;Qian, Puyi;Zhang, Shaofang;Zhou, Hongcheng;Li, Xiuyun;Guan, Chunyu;Du, Shan;Zhang, Yong;Guo, Wei;Chai, Hongliang;Hou, Zhijun

作者机构：

关键词： Diversification; Parascaris univalens; Adaptation; Evolution

期刊名称：BMC GENOMICS （ 影响因子：4.547； 五年影响因子：4.931 ）

ISSN： 1471-2164

年卷期： 2022 年 23 卷 1 期

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收录情况： SCI

摘要： Background The evolution of parasites is often directly affected by the host's environment. Studies on the evolution of the same parasites in different hosts are of great interest and are highly relevant to our understanding of divergence. Methods Here we performed whole-genome sequencing of Parascaris univalens from different Equus hosts (horses, zebras and donkeys). Phylogenetic and selection analyses were performed to study the divergence and adaptability of P. univalens. Results At the genetic level, multiple lines of evidence indicate that P. univalens is mainly separated into two clades (horse-derived and zebra & donkey-derived). This divergence began 300-1000 years ago, and we found that most of the key enzymes related to glycolysis were under strong positive selection in zebra & donkey-derived roundworms, whereas the lipid-related metabolic system was under positive selection in horse-derived roundworms, indicating that the adaptive evolution of metabolism has occurred over the past few centuries. In addition, we found that some drug-related genes showed a significantly higher degree of selection in diverse populations. Conclusions This work reports the adaptive evolution and divergence trend of P. univalens in different hosts for the first time. Its results indicate that the divergence of P. univalens is a continuous, dynamic process. Furthermore, the continuous monitoring of the effects of differences in nutritional and drug histories on the rapid evolution of roundworms is conducive to further understanding host-parasite interactions.

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