Metabolic Profile of 6-Paradol, a Bioactive Compound of Ginger in Mice by High-Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry

文献类型： 外文期刊

第一作者： Zhou, Yu

作者： Zhou, Yu;Xiao, Hang;Chen, Yilu;Shen, Peiyi;Xiao, Hang;Shi, Xiang;Sun, Yue;Liu, Shijun;Zhang, Zhehua;Zheng, Jinkai

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关键词： ginger; 6-paradol; HPLC-Q/TOF MS; metabolites; metabolic pathways

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）

ISSN： 0021-8561

年卷期： 2025 年 73 卷 33 期

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收录情况： SCI

摘要： 6-Paradol is a pungent compound found in ginger, with multiple health benefits. However, the in vivo metabolic fate of 6-paradol remains unclear, which impedes the mechanistic research and application of the compound. This is the first report of an in vivo metabolic study of 6-paradol. Herein, feces and urine samples were collected from mice after dietary administration of 6-paradol for 10 days. High-performance liquid chromatography (HPLC) coupled with quadrupole time-of-flight mass spectrometry (Q/TOF MS) was used to determine the metabolic profile of 6-paradol. A total of 32 metabolites, including 10 phase I metabolites and 22 phase II metabolites, were detected and identified based on the characteristics of their deprotonated ions. Seven phase I metabolites were chemically synthesized for definitive confirmation of their chemical structures, among which 3 compounds were reported for the first time. Our results demonstrated that 6-paradol was metabolized in vivo through demethylation, dehydroxylation, dehydrogenation, hydrogenation, carbon chain breaking, glucuronidation, sulfation, and methyl-thiolation.

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