Preparation and Characterization of Ginger Peel Polysaccharide-Zn (II) Complexes and Evaluation of Anti-Inflammatory Activity

文献类型： 外文期刊

第一作者： Li, Wenwen

作者： Li, Wenwen;Qiu, Zhichang;Zhang, Bin;Li, Lingyu;Zheng, Zhenjia;Ma, Yue;Li, Qiulin;He, Qiuxia

作者机构：

关键词： ginger peel polysaccharide-Zn (II) complexes; synthesis; structural characterization; anti-inflammatory activity; zebrafish

期刊名称：ANTIOXIDANTS （ 影响因子：7.675； 五年影响因子：7.886 ）

ISSN：

年卷期： 2022 年 11 卷 12 期

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收录情况： SCI

摘要： The present study aimed to explore the improvement of the bioactivity of ginger peel polysaccharides (GPs) by the modification of zinc after structural characterization. The obtained GP-Zn (II) complexes consisted dominantly of glucose and galactose in a mass proportion of 95.10:2.10, with a molecular weight of 4.90 x 10(5) Da and a Zn content of 21.17 mg/g. The chelation of GPs and Zn (II) was mainly involved in the O-H of hydroxyl groups, and this interaction reduced the crystallinity and decreased the asymmetry of GPs, with a slight effect on the thermal stability. The administration of GPs and their Zn (II) complexes effectively alleviated CuSO4-induced inflammatory response in zebrafish (Tg: zlyz-EGFP) via down-regulating the mRNA expression levels of pro-inflammatory cytokines (IL-1 beta, IL-6, IL-8, IL-12 and TNF-alpha) and upregulating the expression of anti-inflammatory cytokine (IL-10). Furthermore, the modification of Zn (II) enhanced the inflammation-inhibiting effect of polysaccharides. Therefore, GP-Zn (II) complexes could be applied as a candidate anti-inflammatory agent for the treatment of chronic inflammation-related diseases.

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