Analysis of the eighth intron polymorphism of NR6A1 gene in sheep and its correlation with lumbar spine number

文献类型： 外文期刊

第一作者： Mi, Taotao

作者： Mi, Taotao;Zhang, Yunfeng;Mi, Taotao;Liu, Kaiping;Guo, Tao;Li, Lei;Wang, Yue;Li, Cunyuan;Cui, Yuying;Dai, Jihong;Hu, Shengwei

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关键词： Xinjiang Kazakh sheep; multiple lumbar vertebrae; SNP; PCR-SSCP

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.271； 五年影响因子：1.697 ）

ISSN： 1049-5398

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收录情况： SCI

摘要： For revealing molecular markers related to the traits of multiple lumbar vertebrae in sheep, we analyze the relationship between NR6A1 gene polymorphism and lumbar vertebrae number traits in Xinjiang Kazakh sheep. Lumbar muscle tissues were collected from 6-lumbar spine (L6) Kazak sheep and 7-lumbar spine (L7) Kazak sheep and the intron-8 of NR6A1 gene was amplified by PCR. The SNP locus was detected by the PCR-SSCP method. One-Way ANOVA and an Independent Chi-square Test is adopted to analyze the genotype association with lumbar spine number variation. There were two SNP loci in the intron-8 of the NR6A1 gene: IVS8-188 and IVS8-281. One-Way ANOVA and Independent Chi-square Test indicated a significant association between IVS8-281 and lumbar spine number. The SNP locus of NR6A1 gene intron 8 (IVS8-281G > A) could play a certain role in the variation of lumbar spine number in Xinjiang Kazakh sheep and demonstrates potential to accelerate the sheep breeding of selection process.

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