The TRHDE and TSHR Genes Regulate Laying Traits in Domesticated Zi Geese

文献类型： 外文期刊

第一作者： Zhao, Xiuhua

作者： Zhao, Xiuhua;Yue, Shan;Zhang, Yuanliang;Sun, Jinyan;Peng, Fugang;Guo, Zhenhua

作者机构：

关键词： DNA methylation; egg; goose; RNA-seq

期刊名称：CURRENT ISSUES IN MOLECULAR BIOLOGY （ 影响因子：3.0； 五年影响因子：3.2 ）

ISSN： 1467-3037

年卷期： 2025 年 47 卷 5 期

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收录情况： SCI

摘要： Domestic geese are typically seasonal breeders, and the timing and number of eggs they lay vary depending on the region and breed. Previous studies evaluated the Zi goose, which is currently the domestic goose breed with the highest egg production. This research divided the reproductive cycle into four periods and compared the ovarian RNA-seq and DNA methylation data of Zi geese across these time points to identify the key genes that increase egg production. By integrating differentially expressed genes and differentially methylated genes, we identified 525 candidate genes that presented upregulated expression and hypomethylated regions (the hypo-up group). Ultimately, we found that the thyrotropin-releasing hormone degrading enzyme (TRHDE) and thyroid-stimulating hormone receptor (TSHR) genes play a crucial role in regulating the reproductive cycle of Zi geese. We also generated a proposed model of the relationship between the TRHDE and TSHR genes in Zi geese. This study provides theoretical references for the development of egg-laying goose breeds and raises additional scientific questions for further discussion among researchers.

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