Feeding Eucommia ulmoides extract enhances protection against high-temperature stress in chicks

文献类型： 外文期刊

第一作者： Huang, Youwen

作者： Huang, Youwen;Wang, Yifan;Zhao, Degang;Song, Li;Huang, Youwen;Wang, Yifan;Song, Li;Huang, Youwen;Wang, Yifan;Zhao, Degang;Song, Li;Lei, Yue;Gong, Zouxian;Li, Minxue;Zhao, Degang

作者机构：

关键词： eucommia ulmoide; chick; heat tolerance; immunoregulation; cell cycle

期刊名称：POULTRY SCIENCE （ 影响因子：3.8； 五年影响因子：4.1 ）

ISSN： 0032-5791

年卷期： 2024 年 103 卷 7 期

页码：

收录情况： SCI

摘要： Chick 's susceptibility to heat stress often leads to growth retardation, immune function impairment, disease, and mortality. This thesis explores the potential ameliorative effect of 0.8% Eucommia ulmoides extract ( EUE ) into the diet of heat -stressed chicks in a 15-d feeding trial. The investigation reveals that feeding EUE signi ficantly enhances the BW, ADG, AFI, and F/G of chicks experiencing heat stress. Additionally, the EUE groups exhibited higher levels of T-AOC (at 7 and 15d), SOD (at 15 d), GSH-Px (at 15 d), as well as lower MDA concentrations (at 7 and 15d) in chick serum. Pathological changes and H&E staining revealed that EUE effectively improved tissue damage in the duodenum, heart, and stomach induced by heat stress in the chicks. The EUE groups also showed higher levels of IgA (at 7 d), IgG and IgM (at 7 and 15 d). RNA-seq and WGCNA analysis revealed that EUE mitigates cellular damage and losses in heat -stressed chicks primarily through pathways involving signal transduction, protein synthesis and degradation, as well as cell cycle regulation, particularly the latter. This investigation serves as a fundamental and cognitive framework for the development and application of Eucommia ulmoides feed additives aimed at safeguarding the wellbeing of chicks in adverse environmental conditions.

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