Emerging anthropozoonotic threat in amphibian aquaculture: First report of Trichosporon asahii-induced epidemic with cross-species virulence

文献类型： 外文期刊

第一作者： Wang, Hongbing

作者： Wang, Hongbing;Zhang, Jie;Tian, Yao;Du, Lifei;Wei, Jiaxing;Liu, Junqi;Wang, Hongbing;Zhang, Jie;Liu, Junqi;Kuang, Guangwei;Tang, Xiaoming;Tian, Yao;Hu, Yazhou;Jiang, Yanxia;Wei, Jiaxing;Wang, Sha

作者机构：

关键词： Trichosporon asahii; Bullfrog; Putrid skin; Zoonosis

期刊名称：AQUACULTURE REPORTS （ 影响因子：3.7； 五年影响因子：4.0 ）

ISSN： 2352-5134

年卷期： 2025 年 43 卷

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收录情况： SCI

摘要： Trichosporon asahii, a fungal pathogen predominantly associated with immunocompromised humans, has now been identified as a novel pathogen in amphibian aquaculture. During a 2023 outbreak on a 300,000-individual bullfrog farm in Hunan Province, China, we documented 113,000 mortalities (37.7 % mortality rate) within 60 days, marking the first large-scale epidemic of putrid skin disease in commercial amphibians. Through Koch's postulate fulfillment - isolating seven T. asahii strains from lesions and reproducing disease in laboratoryinfected frogs - we confirmed its causative role. Notably, BALB/c murine models revealed systemic infections, demonstrating mammalian virulence potential. These findings redefine T. asahii as a transboundary pathogen requiring coordinated veterinary-medical interventions and provide epidemiological benchmarks for developing biosecurity protocols in intensive frog farming systems.

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