Structural diversity and biological role of the 5' untranslated regions of picornavirus

文献类型： 外文期刊

第一作者： Peng, Tingyu

作者： Peng, Tingyu;Yang, Fayu;Yang, Fan;Cao, Weijun;Zheng, Haixue;Zhu, Zixiang

作者机构：

关键词： 5' untranslated regions; picornavirus; structure; function; IRES; >

期刊名称：RNA BIOLOGY （ 影响因子：4.1； 五年影响因子：5.0 ）

ISSN： 1547-6286

年卷期： 2023 年 20 卷 1 期

页码：

收录情况： SCI

摘要： The genomic arrangement of most picornavirus of the Picornaviridae family shares a similar monocistronic genomic pattern and a defining organizational feature. A defining feature of picornavirus is the presence of evolutionarily conserved and highly-structured RNA elements in untranslated regions (UTRs) at the genome' 5'and 3' ends, essential for viral replication and translation. Given the diversity and complexity of RNA structure and the limitations of molecular biology techniques, the functional characterization and biological significance of UTRs remain to be fully elucidated, especially for 5' UTR. Here, we summarize the current knowledge of the 5' UTR of picornavirus. This review focuses on the structural characterization and the biological function of the RNA secondary and tertiary structures in the 5' UTR of picornavirus. Understanding the role of the 5' UTR of picornavirus can provide a deep insight into the viral replication cycle and pathogenic mechanisms.

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