Genome-Wide Landscape of mRNAs, lncRNAs, and circRNAs during Testicular Development of Yak

文献类型： 外文期刊

第一作者： La, Yongfu

作者： La, Yongfu;Ma, Xiaoming;Bao, Pengjia;Chu, Min;Yan, Ping;Liang, Chunnian;Guo, Xian;La, Yongfu;Ma, Xiaoming;Bao, Pengjia;Chu, Min;Yan, Ping;Liang, Chunnian;Guo, Xian;La, Yongfu;Ma, Xiaoming;Bao, Pengjia;Chu, Min;Yan, Ping;Liang, Chunnian;Guo, Xian

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关键词： testis; yak; development; non-coding RNA; reproduction

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.6； 五年影响因子：6.2 ）

ISSN：

年卷期： 2023 年 24 卷 5 期

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收录情况： SCI

摘要： Testicular development is a tightly regulated process in mammals. Understanding the molecular mechanisms of yak testicular development will benefit the yak breeding industry. However, the roles of different RNAs, such as mRNA, lncRNA, and circRNA in the testicular development of yak, are still largely unclear. In this study, transcriptome analyses were performed on the expression profiles of mRNAs, lncRNAs, and circRNAs in testis tissues of Ashidan yak at different developmental stages, including 6-months-old (M6), 18-months-old (M18), and 30-months-old (M30). A total of 30, 23, and 277 common differentially expressed (DE) mRNAs, lncRNAs, and circRNAs were identified in M6, M18, and M30, respectively. Furthermore, functional enrichment analysis showed that the common DE mRNAs during the entire developmental process were mainly involved in gonadal mesoderm development, cell differentiation, and spermatogenesis processes. Additionally, co-expression network analysis identified the potential lncRNAs related to spermatogenesis, e.g., TCONS_00087394 and TCONS_00012202. Our study provides new information about changes in RNA expression during yak testicular development, which greatly improves our understanding of the molecular mechanisms regulating testicular development in yaks.

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