Tartary Buckwheat Flavonoids Improve Colon Lesions and Modulate Gut Microbiota Composition in Diabetic Mice

文献类型： 外文期刊

第一作者： Cheng, Wenwen

作者： Cheng, Wenwen;Cai, Cifeng;Liao, Zhiyong;Kreft, Ivan;Turnsek, Tamara Lah;Zu, Mingyan;Hu, Yongping;Zhou, Meiliang

作者机构：

期刊名称：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE （ 影响因子：2.65； 五年影响因子：3.014 ）

ISSN： 1741-427X

年卷期： 2022 年 2022 卷

页码：

收录情况： SCI

摘要： Tartary buckwheat flavonoids (TBFs) exhibit diverse biological activities, with antioxidant, antidiabetes, anti-inflammatory, and cholesterol-lowering properties. In this study, we investigated the role of TBFs in attenuating glucose and lipid disturbances in diabetic mice and hence preventing the occurrence of diabetes-related colon lesions in mice by regulating the gut microbiota. The results showed that TBFs (1) reversed blood glucose levels and body weight changes; (2) improved levels of serum total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and fasting insulin; and (3) significantly reduced diabetes-related colon lesions in diabetic mice. In addition, TBFs also affected the diabetes-related imbalance of the gut microbiota and enriched beneficial microbiota, including Akkermansia and Prevotella. The TBF also selectively increased short-chain fatty acid-producing bacteria, including Roseburia and Odoribacter, and decreased the abundance of the diabetes-related gut microbiota, including Escherichia, Mucispirillum, and Bilophila. The correlation analysis indicated that TBFs improved metabolic parameters related to key communities of the gut microbiota. Our data suggested that TBFs alleviated glucose and lipid disturbances and improved colon lesions in diabetic mice, possibly by regulating the community composition of the gut microbiota. This regulation of the gut microbiota composition may explain the observed effects of TBFs to alleviate diabetes-related symptoms.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序