A Review of the Bromodomain and Extraterminal Domain Epigenetic Reader Proteins: Function on Virus Infection and Cancer

文献类型： 外文期刊

第一作者： Wu, Mengli

作者： Wu, Mengli;Guan, Guiquan;Yin, Hong;Niu, Qingli;Wu, Mengli;Guan, Guiquan;Yin, Hong;Niu, Qingli;Yin, Hong

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关键词： BET family; transcription; viral infection; inhibitors; cancer

期刊名称：VIRUSES-BASEL （ 影响因子：3.8； 五年影响因子：4.0 ）

ISSN：

年卷期： 2024 年 16 卷 7 期

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收录情况： SCI

摘要： The BET (bromodomain and extraterminal domain) family of proteins, particularly BRD4 (bromodomain-containing protein 4), plays a crucial role in transcription regulation and epigenetic mechanisms, impacting key cellular processes such as proliferation, differentiation, and the DNA damage response. BRD4, the most studied member of this family, binds to acetylated lysines on both histones and non-histone proteins, thereby regulating gene expression and influencing diverse cellular functions such as the cell cycle, tumorigenesis, and immune responses to viral infections. Given BRD4's involvement in these fundamental processes, it is implicated in various diseases, including cancer and inflammation, making it a promising target for therapeutic development. This review comprehensively explores the roles of the BET family in gene transcription, DNA damage response, and viral infection, discussing the potential of targeted small-molecule compounds and highlighting BET proteins as promising candidates for anticancer therapy.

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