The novel function of an orphan pheromone receptor reveals the sensory specializations of two potential distinct types of sex pheromones in noctuid moth

文献类型： 外文期刊

第一作者： Wang, Chenrui

作者： Wang, Chenrui;Guo, Mengbo;Sun, Dongdong;Wang, Guirong;Liu, Yang;Cao, Song;Wang, Guirong;Cao, Song;Shi, Chen;Xiu, Peng;Guo, Mengbo;Liu, Zheyi;Wang, Yong;Wang, Yong

作者机构：

关键词： Helicoverpa armigera; Type II sex pheromone; Pheromone receptor; Olfactory sensilla; Molecular docking

期刊名称：CELLULAR AND MOLECULAR LIFE SCIENCES （ 影响因子：6.2； 五年影响因子：7.7 ）

ISSN： 1420-682X

年卷期： 2024 年 81 卷 1 期

页码：

收录情况： SCI

摘要： Sex pheromones play crucial role in mating behavior of moths, involving intricate recognition mechanisms. While insect chemical biology has extensively studied type I pheromones, type II pheromones remain largely unexplored. This study focused on Helicoverpa armigera, a representative species of noctuid moth, aiming to reassess its sex pheromone composition. Our research unveiled two previously unidentified candidate type II sex pheromones-3Z,6Z,9Z-21:H and 3Z,6Z,9Z-23:H-in H. armigera. Furthermore, we identified HarmOR11 as an orphan pheromone receptor of 3Z,6Z,9Z-21:H. Through AlphaFold2 structural prediction, molecular docking, and molecular dynamics simulations, we elucidated the structural basis and key residues governing the sensory nuances of both type I and type II pheromone receptors, particularly HarmOR11 and HarmOR13. This study not only reveals the presence and recognition of candidate type II pheromones in a noctuid moth, but also establishes a comprehensive structural framework for PRs, contributing to the understanding of connections between evolutionary adaptations and the emergence of new pheromone types.

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