Identification and analysis of the degradation products of chlorothalonil in vegetables

文献类型： 外文期刊

第一作者： Li, Nan

作者： Li, Nan;Xia, Yining;Xu, Yanyang;Li, Yun;Jia, Qi;Qiu, Jing;Qian, Yongzhong;Wang, Zian;Liu, Zhe

作者机构：

关键词： Untargeted screening; Sulfhydryl chlorothalonil; Hydroxyl chlorothalonil; Simultaneous analysis; Vegetables

期刊名称：JOURNAL OF CHROMATOGRAPHY A （ 影响因子：4.601； 五年影响因子：4.313 ）

ISSN： 0021-9673

年卷期： 2022 年 1686 卷

页码：

收录情况： SCI

摘要： In this study, the untargeted screening of the degradation products of chlorothalonil (CHT) in vegetables was performed using ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS). Sulfhydryl-CHT (SH-CHT) and hydroxyl CHT (OH-CHT) were screened as the key degrada-tion products of CHT in vegetables. SH-CHT is a new degradation product of CHT in the vegetables. This study was the first discover the SH-substituted degradation product of pesticide in vegetables. The chem-ical structure of SH-CHT was deduced and confirmed through synthetic reference. An efficient method for the simultaneous monitoring of SH-CHT and hydroxyl CHT (OH-CHT) in vegetables has been proposed based on QuEChERS in combination with HPLC-MS/MS analysis. The recoveries of SH-CHT and OH-CHT were in range of 85.8%-105.1% with intra-and inter-relative standard deviation (RSD) of less than 10.0%. The limits of detection were 2.0 mu g/kg for SH-CHT and 0.2 mu g/kg for OH -CHT. Seven kinds of vegetables covering various plant families were processed with CHT. As a result, SH-CHT was detected in five kinds of sulfur-rich vegetables with transformation rates of 7.6%-26.6%. OH-CHT was detected in all the veg-etables with transformation rates of 1.7%-14.0%. Toxicity evaluation based on ECOSAR program indicated that SH-CHT had potentially high toxicity to aquatic organisms. This study provides a powerful approach for the monitoring and risk assessment of SH-CHT and OH-CHT in food safety control. Furthermore, the study inspires comprehensive research on the overlooked degradation pathways of pesticides in sulfur -rich vegetables. (c) 2022 Elsevier B.V. All rights reserved.

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