文献类型： 外文期刊
第一作者： Geng, Hui-Chun
作者： Geng, Hui-Chun;Chen, Ning;Lv, Jun-Jiang;Zhou, Min;Geng, Hui-Chun;Chen, Ning;Lv, Jun-Jiang;Zhou, Min;Geng, Hui-Chun;Wang, Xue-Song;Lv, Jun-Jiang
作者机构：
关键词： Lepidium meyenii; Thioureas; ECD; Cytotoxicity
期刊名称：FITOTERAPIA （ 影响因子：3.4； 五年影响因子：3.3 ）
ISSN： 0367-326X
年卷期： 2023 年 168 卷
页码：
收录情况： SCI
摘要： Macathioureas A-D (1-4), four new thiourea derivatives with a carbamothioylpyrrolidine-2-carboxamide framework, were isolated from the roots of Lepidium meyenii (Maca) collected from Qujing, Yunnan Province of China. Their structures were identified based on extensive spectroscopic data, including 1D NMR, 2D NMR, and HRESIMS techniques. Their absolute configurations were assigned as 7S by the comparison of the experi-mental and predicted electronic circular dichroism (ECD) spectra. All the thiourea analogues were tested for their cytotoxicities against five human cancer cell lines. However, no significant activities were detected at concen-trations up to 40 mu M.
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