Study on the Bioactivity, Toxicity, Stereoselective Fate, and Risk Assessment of Chiral Fungicide Isopyrazam in Five Kinds of Fruits and Vegetables

文献类型： 外文期刊

第一作者： Wang, Xinquan

作者： Wang, Xinquan;Diao, Ziyang;Cang, Tao;Zhao, Huiyu;Qi, Peipei;Wang, Zhiwei;Liu, Zhenzhen;Di, Shanshan;Wang, Xinquan;Diao, Ziyang;Cang, Tao;Zhao, Huiyu;Qi, Peipei;Wang, Zhiwei;Liu, Zhenzhen;Di, Shanshan

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关键词： isopyrazam stereoisomers; stereoselectivity; bioactivity; acute toxicity; degradation

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）

ISSN： 0021-8561

年卷期： 2024 年 72 卷 40 期

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收录情况： SCI

摘要： Isopyrazam (IPZ) is a new chiral fungicide. For bioactivity, there was a 3.37-1578 times difference among the four stereoisomers. For Alternaria alternata and Phoma multirostrata, cis-(1S,4R,9S)-IPZ had the greatest activity. Using cis-IPZ might improve the efficacy and reduce the dosage of the racemate by 54.7-72.2% for A. alternata and P. multirostrata. To zebrafish, trans-IPZ showed the highest acute toxicity (LC50, 0.096 mg/L). The degradation half-lives of IPZ stereoisomers in the five crops ranged from 3.50 to 15.2 days. Cis-IPZ was preferentially degraded in grape, pear, and celery. The residual concentrations of IPZ in grape and celery were still higher than the maximum residue limit, and the acute and chronic dietary intake risks of IPZ in celery were unacceptable (RQ(a): 146-250%, HQ: 117-200%), which were worthy of further researching. Based on the research results, it is safer and more reasonable to use IPZ in the form of a racemate with a high ratio of cis-IPZ.

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