Comprehensive Human Milk Patterns Are Related to Infant Growth and Allergy in the CHMP Study

文献类型： 外文期刊

第一作者： Jiang, Shilong

作者： Jiang, Shilong;Pan, Jiancun;Li, Yuanyuan;Ju, Mengnan;Zhang, Wei;Li, Kaifeng;Jiang, Shilong;Pan, Jiancun;Li, Yuanyuan;Ju, Mengnan;Zhang, Wei;Li, Kaifeng;Lu, Jing;Lv, Jiaping;Lu, Jing

作者机构：

关键词： glycome; human milk patterns; lipidome; proteome; the Chinese Human Milk Project

期刊名称：MOLECULAR NUTRITION & FOOD RESEARCH （ 影响因子：5.82； 五年影响因子：6.366 ）

ISSN： 1613-4125

年卷期： 2021 年 65 卷 17 期

页码：

收录情况： SCI

摘要： Scope The aim of the present study is to identify human milk pattern using multi-omics datasets and to explore association between patterns, infant growth, and allergy using data from the Chinese Human Milk Project (CHMP) study. Methods and Results Three patterns are identified from integrative analysis of proteome, lipidome, and glycome profiles of 143 mature human milk samples. Factor 1 is positively associated with 128 proteins, phospholipids, and human milk oligosaccharides (HMOs) including lacto N-neohexaose (LNnH) and lacto-N-difucohexaose II (LNDFH II); factor 2 is negatively associated with as(1)-casein, phospholipids while positively associates with HMOs including LNnH, lactosialyl tetrasaccharide c (LSTc), and 2'-fucosyllactose (2'FL); factor 3 is positively associated with lysophospholipids while negatively associates with 27 proteins, triglycerides with two saturated fatty acids, 6'-sialyllactose (6'SL) and 2'FL. In general, factor 1 and factor 2 are associated with slower while factor 3 is associated with faster growth rate (p < 0.044). One unit higher in loadings of factor 2 is associated with 34% lower risk of allergies (p <= 0.017). Associations are not significant after adjustment for city except for factor 1. Conclusions Three possible human milk patterns with varying degree of stability are identified. Future work is needed to understand these patterns in terms of generalization, biologic mechanisms, and genotype influences.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序