Development of 1,5-Diaryl-Pyrazole-3-Formate Analogs as Antifungal Pesticides and Their Application in Controlling Peanut Stem Rot Disease

文献类型： 外文期刊

第一作者： Ma, Yihui

作者： Ma, Yihui;Yang, Jun;Yang, Dangwei;Qin, Guangyu;Zu, Junhuai

作者机构：

关键词： 1,5-diaryl-pyrazole-3-formate; antifungal pesticides; peanut stem rot disease; synthesis; Sclerotium rolfsii

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：6.064； 五年影响因子：6.843 ）

ISSN：

年卷期： 2022 年 12 卷

页码：

收录情况： SCI

摘要： Stem rot disease caused by Sclerotium rolfsii is one of the destructive diseases in peanut and poses a big risk to peanut production. Current fungicides in the market have not provided satisfactory control efficacy and thus called for novel fungicides with different structures as an alternative treatment strategy. Our previously developed phenylpyrazole compound 3c demonstrated modest inhibitory effect against S. rolfsii. The following structure modification identified an unreported compound 6, which bears a 3-chloropyridinyl moiety as the most prominent derivative with an IC50 of 12 mu g/ml in potato dextrose agar (PDA) assay, higher than those of 0.8 and 1.8 mu g/ml associated with thifluzamide and tebuconazole, respectively. However, compound 6 showed similar controlling effects to those of thifluzamide and tebuconazole in field study. This study underscores the potential of 1,5-diaryl-pyrazole-3-formate as an antifungal candidate for stem rot disease management.

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