Sequential Immunization with Vaccines Based on SARS-CoV-2 Virus-like Particles Induces Broadly Neutralizing Antibodies

文献类型： 外文期刊

第一作者： Mi, Youjun

作者： Mi, Youjun;Mi, Youjun;Wang, Wenting;Kong, Weize;Xu, Xiaonan;Rong, Xifeng;Tan, Jiying;Xu, Kun;Wang, Wenting;Kong, Weize;Xu, Xiaonan;Rong, Xifeng;Tan, Jiying;Xu, Kun;Wang, Wenting;Kong, Weize;Xu, Xiaonan;Rong, Xifeng;Tan, Jiying;Xu, Kun

作者机构：

关键词： virus-like particle (VLP); SARS-CoV-2 variant; prime-boost; sequential immunization; broadly neutralizing antibody

期刊名称：VACCINES （ 影响因子：3.4； 五年影响因子：3.7 ）

ISSN：

年卷期： 2024 年 12 卷 8 期

页码：

收录情况： SCI

摘要： Although many people have been vaccinated against COVID-19, infections with SARS-CoV-2 seem hard to avoid. There is a need to develop more effective vaccines and immunization strategies against emerging variants of infectious diseases. To understand whether different immunization strategies using variants sequence-based virus-like particles (VLPs) vaccines could offer superior immunity against future SARS-CoV-2 variants, our team constructed VLPs for the original Wuhan-Hu-1 strain (prototype), Delta (delta) variant, and Omicron (omicron) variant of SARS-CoV-2, using baculovirus-insect expression system. Then we used these VLPs to assess the immune responses induced by homologous prime-boost, heterologous prime-boost, and sequential immunizations strategies in a mouse model. Our results showed that the pro+delta+omicron sequential strategies elicited better neutralizing antibody responses. These sequential strategies also take advantage of inducing CD4+ T and CD8+ T lymphocytes proliferation and tendency to cytokine of Th1. Currently, our data suggest that sequential immunization with VLPs of encoding spike protein derived from SARS-CoV-2 variants of concern may be a potential vaccine strategy against emerging diseases, such as "Disease X".

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序