Evolution of MHC class I genes in two ancient fish, paddlefish (Polyodon spathula) and Chinese sturgeon (Acipenser sinensis)

文献类型: 外文期刊

第一作者: Wang, Dengqiang

作者: Wang, Dengqiang;Zhong, Lei;Gan, Xiaoni;He, Shunping;Wang, Dengqiang;Wei, Qiwei;Wang, Dengqiang

作者机构:

关键词: Major histocompatibility complex;Trans-species polymorphism;Evolution;Recombination;Polyodon spathula;Acipenser sinensis

期刊名称:FEBS LETTERS ( 影响因子:4.124; 五年影响因子:3.814 )

ISSN: 0014-5793

年卷期: 2010 年 584 卷 15 期

页码:

收录情况: SCI

摘要: Here we present the first isolation of major histocompatibility complex (MHC) class I genes from two ancient fish, paddlefish (Polyodon spathula) and Chinese sturgeon (Acipenser sinensis). Seventeen sequences obtained showed high polymorphism and positive natural selection with d(N)/d(S) > 1. Evolutionary relationships revealed that sequences from paddlefish and Chinese sturgeon distinguished from other vertebrate class I and had an intermingling of alleles, which indicates that Acipenseriformes have a common ancestral gene of class I and a trans-species polymorphism across Acipenseriformes. We also found clear evidence of recombination among class I genes of paddlefish and Chinese sturgeon. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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