17α-methyltestosterone exposure disrupted growth, liver physiology and intestinal microbial on fish: A case study on migratory bony fishes ( Takifugu fasciatus)

文献类型： 外文期刊

第一作者： Liu, Yuxi

作者： Liu, Yuxi;Wang, Sijin;Han, Mengbo;Luo, Sheng;Chu, Peng;Tang, Xiaodong;Zhao, Cheng;Yin, Shaowu;Wang, Tao;Liu, Yuxi;Wang, Sijin;Han, Mengbo;Luo, Sheng;Chu, Peng;Tang, Xiaodong;Zhao, Cheng;Yin, Shaowu;Wang, Tao;Han, Shiqun

作者机构：

关键词： 17 alpha-methyltestosterone; Takifugu fasciatus; Lipid physiological metabolism; Intestinal microorganisms

期刊名称：MARINE POLLUTION BULLETIN （ 影响因子：4.9； 五年影响因子：5.6 ）

ISSN： 0025-326X

年卷期： 2025 年 212 卷

页码：

收录情况： SCI

摘要： 17 alpha-methyltestosterone (17 alpha-MT) is prevalent in the aqueous environment, but its toxicological profile remains incomplete. This study analyzed the effects of different 17 alpha-MT concentrations on the growth performance, mortality, sex ratio, liver physiological metabolism, and intestinal microorganisms of Takifugu fasciatus, and on the microorganisms composition of its culture environment. Results showed that 17 alpha-MT increased the male ratio and mortality but inhibited the growth of T. fasciatus. Meanwhile, 17 alpha-MT induced oxidative stress and mitochondrial autophagy, changed lipid metabolism and inhibited triglyceride (TG) accumulation in the liver. 17 alpha-MT altered the composition of the intestinal microorganisms, notably increasing the number of pathogenic bacteria. Additionally, the Firmicutes to the Bacteroidetes (F/B) ratio, associated with lipid metabolism, decreased with increasing 17 alpha-MT concentration. Furthermore, 17 alpha-MT disrupted the connection between the intestine microorganisms in T. fasciatus and the water column. This study enhances understanding of the effect of 17 alpha-MT on T. fasciatus and the toxicological profile of 17 alpha-MT.

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