Two new phenanthrene derivatives from Pholidota chinensis

文献类型： 外文期刊

第一作者： Wang, De-Lei

作者： Wang, De-Lei;Lin, Fang-Xia;Tang, Min-Min;Zhou, Xue-Ming;Yi, Ji-Ling;Wang, Tian-Tian;Tang, Min-Min;Wang, De-Lei;Lin, Fang-Xia;Zhou, Xue-Ming;Yi, Ji-Ling;Wang, Tian-Tian

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关键词： Pholidota chinensis; Phenanthrenes; Cytotoxic activity

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）

ISSN： 1874-3900

年卷期： 2021 年 43 卷

页码：

收录情况： SCI

摘要： Two new phenanthrene derivatives, 2,3,7-trihydroxy-5H-phenanthro[4,5-bcd] pyran (1) and 2,3-dihydroxy-7methoxy-5H-phenanthro[4,5-bcd] pyran (2) together with four known phenanthrenes derivatives (3-6) were isolated from the aerial parts of Pholidota chinensis Lindl. The structure of the new compounds 1 and 2 was determined by 1D and 2D NMR, as well as HRESIMS. The inhibitory activities of all compounds against four cancer cell lines were evaluated. Compounds 1 and 3 showed the highest cytotoxicity against the MCF-7 cell lines (IC50 = 8.1 and 7.5 mu M). The other compounds showed modest activities or were inactive.

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