Identification and verification of the role of key metabolites and metabolic pathways on ASFV replication

文献类型： 外文期刊

第一作者： Shi, Zunji

作者： Shi, Zunji;Yang, Xing;Shi, Xijuan;Zhang, Dajun;Zhao, Dengshuai;Hao, Yu;Yang, Jinke;Bie, Xintian;Yan, Wenqian;Chen, Guohui;Chen, Lingling;Liu, Xiangtao;Zheng, Haixue;Zhang, Keshan;Shi, Zunji;Zhang, Keshan;Zhang, Keshan

作者机构：

期刊名称：ISCIENCE （ 影响因子：5.8； 五年影响因子：5.8 ）

ISSN：

年卷期： 2024 年 27 卷 4 期

页码：

收录情况： SCI

摘要： African swine fever virus (ASFV) infection usually causes viremia within a few days. However, the metabolic changes in pig serum after ASFV infection remain unclear. In this study, serum samples collected from ASFV-infected pigs at different times were analyzed using pseudotargeted metabolomics method. Metabolomic analysis revealed the dopaminergic synapse pathway has the highest rich factor in both ASFV5 and ASFV10 groups. By disrupting the dopamine synaptic pathway, dopamine receptor antagonists inhibited ASFV replication and L-dopa promoted ASFV replication. In addition, guanosine, one of the top20 changed metabolites in both ASFV5 and ASFV10 groups suppressed the replication of ASFV. Taken together, this study revealed the changed serum metabolite profiles of ASFV-infected pigs at various times after infection and verified the effect of the changed metabolites and metabolic pathways on ASFV replication. These findings may contribute to understanding the pathogenic mechanisms of ASFV and the development of target drugs to control ASF.

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