Development and validation of an ultra performance liquid chromatography-tandem mass spectrometry method for twelve bisphenol compounds in animal feed

文献类型： 外文期刊

第一作者： Wang, Ruiguo

作者： Wang, Ruiguo;Dong, Shujun;Wang, Peilong;Li, Tong;Huang, Yuan;Su, Xiaoou;Zhao, Lijuan

作者机构：

关键词： Bisphenol; Feed; Determiation; Post-column infusion; UPLC-MS; MS

期刊名称：JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES （ 影响因子：3.205； 五年影响因子：3.068 ）

ISSN： 1570-0232

年卷期： 2021 年 1178 卷

页码：

收录情况： SCI

摘要： Bisphenol compounds (BPs) are a group of environmental contaminants with endocrine-disrupting effects both for humans and animals. The present work developed a sensitive analytical method for the detection of multiple BPs in the animal feed based on ultra performance liquid chromatography-tandem mass spectrometry (UPLCMS/MS) with post-column ammonium hydroxide (NH4OH) infusion. A modified QuEChERS method was incorporated into the extraction and purification processes. The limit of detection (LODs) and quantification (LOQs) for the target BPs were in the ranges of 0.02-0.75 mu g kg-1 and 0.04-0.95 mu g kg-1, respectively. Average recoveries were ranged between 82.6% and 112%. The proposed method was successfully applied to determine the concentrations of BPs in 20 actual feed samples, and the preliminary profiles of BPs in products from local feed factories were obtained. Each sample was simultaneously contaminated with at least 2 to 4 BPs, and bisphenol A (BPA) was the dominant analog of BPs found in animal feed.

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