The genome of the thin-necked bladder worm Taenia hydatigena reveals evolutionary strategies for helminth survival

文献类型： 外文期刊

第一作者： Wang, Shuai

作者： Wang, Shuai;Liu, Zhongli;Wang, Yugui;Guo, Aijiang;Wang, Qianhao;Zhang, Shaohua;Luo, Xuenong;Zhu, Xing-quan;Cai, Xuepeng;Liu, Xiaolin;Huang, Wanlong;Zhu, Guan;Zhu, Guan

作者机构：

期刊名称：COMMUNICATIONS BIOLOGY （ 影响因子：6.268； 五年影响因子：6.268 ）

ISSN：

年卷期： 2021 年 4 卷 1 期

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收录情况： SCI

摘要： Wang and colleagues report a high quality draft genome for the thin-necked bladder worm, an agricultural livestock parasitic pest. Using this draft genome and comparison with other related parasites, they reveal gene families that are selectively pressured in different species, indicative of specialised survival strategies for different hosts. Taenia hydatigena is a widespread gastrointestinal helminth that causes significant health problems in livestock industry. This parasite can survive in a remarkably wide range of intermediate hosts and affects the transmission dynamics of zoonotic parasites. T. hydatigena is therefore of particular interest to researchers interested in studying zoonotic diseases and the evolutionary strategies of parasites. Herein we report a high-quality draft genome for this tapeworm, characterized by some hallmarks (e.g., expanded genome size, wide integrations of viral-like sequences and extensive alternative splicing during development), and specialized adaptations related to its parasitic fitness (e.g., adaptive evolutions for teguments and lipid metabolism). Importantly, in contrast with the evolutionarily close trematodes, which achieve gene diversification associated with immunosuppression by gene family expansions, in T. hydatigena and other cestodes, this is accomplished by alternative splicing and gene loss. This indicates that these two classes have evolved different mechanisms for survival. In addition, molecular targets for diagnosis and intervention were identified to facilitate the development of control interventions. Overall, this work uncovers new strategies by which helminths evolved to interact with their hosts.

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