Foxtail millet prolamin-pectin nanoparticles enhanced the stability and bioavailability of β-sitosterol
文献类型： 外文期刊
第一作者： Li, Yue
作者： Li, Yue;Qiao, Jiawei;Xing, Bao;Yun, Junyan;Niu, Jiahui;Chen, Muwen;Yang, Pu;Zhao, Shaojie;Zhang, Lizhen;Liu, Yongxia
作者机构：
关键词： beta-Sitosterol; Foxtail millet prolamin; Pectin; Nanoparticle; Biological accessibility
期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：8.0； 五年影响因子：8.5 ）
ISSN： 0963-9969
年卷期： 2025 年 205 卷
页码：
收录情况： SCI
摘要： Herein, beta-sitosterol-loaded foxtail millet prolamin (FMP)-pectin composite nanoparticles (FSNs) were successfully produced using an antisolvent precipitation method to encapsulate beta-sitosterol and improve its bioaccessibility. Results indicated that the nanoparticles prepared at a FMP-to-pectin mass ratio of 10:2 not only showed lower particle size (401.7 +/- 14.7 nm, p < 0.05) and higher net zeta potential (-33.3 +/- 6.1 mV, p < 0.05) but also exhibited higher encapsulation efficiency (81.5 % +/- 0.3 %, p < 0.05). FSNs successfully encapsulated beta-sitosterol through electrostatic and hydrophobic interactions and hydrogen bonding. beta-sitosterol changed from a crystalline to an amorphous state. Meanwhile, FMP-pectin composite nanoparticles (FNs) and FSNs displayed similar irregular lamellar structures and exhibited excellent physical stability at different environments (pH > 4, salt ions <100 mM, different temperatures and storage at 4 degrees C). The simulated digestion result showed that FSNs could target the release of beta-sitosterol at the intestinal stage with a release rate of 72.23 +/- 1.19 % (p < 0.05). Moreover, the bioaccessibility of beta-sitosterol in FSNs significantly increased by about 68.58 +/- 2.39 % (p < 0.05) compared with free beta-sitosterol. Nonetheless, this study provided a novel beta-sitosterol delivery system based on FMP-pectin complexes with a broad prospect in the processing of food, pharmaceuticals and nutrition.
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