Development of a Cation Exchange SPE-HILIC-MS/MS Method for the Determination of Ningnanmycin Residues in Tea and Chrysanthemum

文献类型： 外文期刊

第一作者： Li, Aiping

作者： Li, Aiping;Wang, Chen;Wu, Zhenghao;Liu, Yingying;Hao, Zhenxia;Lu, Chengyin;Chen, Hongping;Li, Aiping;Wu, Zhenghao;Liu, Yingying;Wang, Chen;Chen, Hongping;Wang, Chen;Hao, Zhenxia;Lu, Chengyin;Chen, Hongping

作者机构： Chinese Acad Agr Sci, Tea Res Inst, Hangzhou 310008, Peoples R China;Chinese Acad Agr Sci, Grad Sch, Beijing 100081, Peoples R China;Minist Agr & Rural Affairs, Lab Qual & Safety Risk Assessment Tea Prod Hangzho, Hangzhou 310008, Peoples R China;Minist Agr & Rural Affairs, Key Lab Tea Qual & Safety Control, Hangzhou 310008, Peoples R China

关键词： ningnanmycin; tea; chrysanthemum; cation exchange; HILIC-MS/MS

期刊名称：FOODS （ 2022影响因子：5.2； 五年影响因子：5.5 ）

ISSN：

年卷期： 2024 年 13 卷 5 期

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收录情况： SCI

摘要： Ningnanmycin is a widely used antibiotic in agricultural production that effectively controls fungal and viral diseases in tea trees and chrysanthemums. The polarity characteristic of ningnanmycin has posed limitations on the development of robust detection methods, thereby hindering effective monitoring and control measures. By combining cation exchange solid phase extraction (SPE) with hydrophilic interaction chromatography tandem mass spectrometry (HILIC-MS/MS), we have effectively tackled the issue pertaining to the separation and retention of ningnanmycin. The average recoveries of ningnanmycin in green tea, black tea, and chrysanthemum were 77.3-82.0%, 80.1-81.5%, and 74.0-80.0%, respectively. The intraday and interday relative standard deviations (RSDs) were below and equal to 7.7%. Good linearity was observed in the concentration range of 1-1000 mu g/L (R2 > 0.998). The limits of detection (LODs) ranged from 1.1 mu g/kg to 7.1 mu g/kg, and the limits of quantification (LOQs) ranged from 3.6 mu g/kg to 23.7 mu g/kg for ningnanmycin. These results indicate the good accuracy, repeatability, reproducibility, and sensitivity of the method. It is suitable for detecting ningnanmycin in tea and chrysanthemum.

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